Foxl1-2A-CreERT2
品系全名
C57BL/6Smoc-Foxl1em1(2A-CreERT2)Smoc
目錄號
NM-KI-00135
品系狀態(tài)
活體
基因信息
基因名
Foxl1
品系描述
驗證數(shù)據(jù)
Fig 1. CreERT2-mediated recombination in small intestine of Foxl1CreERT2/+; Rosa26tdTomato/+ mice.
Fig 2. Detection of tdTomato (red) in various tissues of Foxl1CreERT2/+; Rosa26tdTomato/+ mice. Expression tissues include: small intestine, colon, stomach,lung, kidney, ovary. A few cells expressed in brain, adrenal gland, muscle, thymus. Tissues that unexpressed include retina, liver, salivary glands, brown fat, pancreas, spleen, skin. (4.5-month old, female) (For more detailed information please contact our technical advisor.)?
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Cre-ERT2在無Tamoxifen誘導(dǎo)的情況下,在細(xì)胞質(zhì)內(nèi)處于無活性狀態(tài);當(dāng)Tamoxifen誘導(dǎo)后,Tamoxifen的代謝產(chǎn)物4-OHT(雌激素類似物)與ERT結(jié)合,可使Cre-ERT2進(jìn)核發(fā)揮Cre重組酶活性。
查看常見的基因工程小鼠可以分為兩種命名方式,包括基因定點修飾的小鼠命名,比如:敲除、敲入、點突變等等,和隨機轉(zhuǎn)基因的小鼠命名。
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