CUMS模型與人類抑郁癥吻合程度高，可以更好地模擬人類長(zhǎng)期在各種環(huán)境中受到的各種低水平刺激所引起的反應(yīng)，被認(rèn)為是目前最經(jīng)典的動(dòng)物模型。造模方法通常是將C57BL/6小鼠置于溫和應(yīng)激刺激環(huán)境下（如電擊足底、通宵照明、禁水、禁食、換籠飼養(yǎng)、晝夜顛倒、束縛等），作用數(shù)周或數(shù)月后，使小鼠表現(xiàn)出抑郁狀態(tài)。
Fig1. Depression mouse model by chronic unpredictable mildness stimulation. After 6 to 8 weeks of stimulation, mice in the model group exhibited a decrease in the sugar-water preference index (indicating anhedonia) and an increase in the immobility time of the forced swim test and the hanging tail test (indicating a state of despair).
