博萊霉素（bleomycin，BLM）是一種腫瘤藥物，對(duì)肺部存在毒性副作用。該藥可以誘導(dǎo)DNA的斷裂與氧化應(yīng)激反應(yīng)，從而引起實(shí)質(zhì)炎癥、上皮細(xì)胞損傷伴反應(yīng)性增生、上皮-間充質(zhì)轉(zhuǎn)化、成纖維細(xì)胞活化并分化為肌成纖維細(xì)胞，以及基底膜和肺泡上皮損傷等癥狀。
Fig.1 Bleomycin induced pulmonary fibrosis in C57BL/6 (male, 10-12w) mice. (A) Body Weight. (B) Body Weight Change. (C) Survival Curve.?
Fig2.Bleomycin induced pulmonary fibrosis in C57BL/6 (male, 10-12w) mice.?(A) H&E and Masson stain. (B) Alveolar inflammation score. (C)Alveolar fibrosis score.
