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雄激素脫發(fā)疾病模型

疾病簡(jiǎn)介

雄激素性脫發(fā)(androgenetic alopecia,AGA),是一種受遺傳因素和雄激素影響的脫發(fā)類(lèi)型,表現(xiàn)為頭頂和前額的脫發(fā)。男性和女性都可能受到影響,但在男性中更為普遍和顯著。雄激素性脫發(fā)的特點(diǎn)是頭發(fā)逐漸變薄,最終導(dǎo)致部分或全部禿頂。目前,有多種治療方法可以幫助減緩脫發(fā)過(guò)程或促進(jìn)頭發(fā)再生,包括藥物治療、激光治療和毛發(fā)移植等。

疾病模型

南模生物長(zhǎng)期致力于自身免疫性疾病相關(guān)研究,開(kāi)發(fā)了多種脫發(fā)小鼠模型,為相關(guān)藥物的藥效評(píng)估和安全性評(píng)價(jià)提供了強(qiáng)有力的工具。

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After an acclimatization period of 7 days, the dorsal skin area of approximately 2 × 2 cm was depilated for all mice (Day 0).

Control group: Treated with saline; Model group: Treated with testosterone propionate; Treatment group: Treated with testosterone propionate + minoxidil tincture.

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Fig.1 clinical symptoms of androgenetic alopecia mouse model and statistical data analysis, other analysis are on going.

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Fig.2 Representative images of H&E pathological results. Blue arrow means normal hair follicle.

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