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疾病簡(jiǎn)介

銀屑?。╬soriasis）是一種常見并易復(fù)發(fā)的慢性炎癥性皮膚病，具有特征性紅色丘疹、斑塊及銀白色鱗屑，頑固難治，頻繁復(fù)發(fā)，罹患終身等特點(diǎn)，其發(fā)病原因及發(fā)病機(jī)制均尚未完全明晰，目前認(rèn)為是遺傳和環(huán)境因素共同作用導(dǎo)致。

疾病模型

南模生物長期致力于自身免疫性疾病相關(guān)研究，開發(fā)了多種銀屑病小鼠模型，為相關(guān)藥物的藥效評(píng)估和安全性評(píng)價(jià)提供了強(qiáng)有力的工具。

IMQ誘導(dǎo)的hIL17A/hIL17F人源化小鼠銀屑病模型及藥效評(píng)價(jià)

Fig.1 Body weight (A) and body weight change (B) of IMQ induced Psoriasis model in hIL17A/hIL17F mice. (n=6).?

Test article 1 and test article 2 are from a collaborator.

Fig.2 IMQ induced Psoriasis model in hIL17A/hIL17F mice.?(A) ear thickness (B) skin thickness (C) clinical score (n=6).?

Test article 1 and test article 2 are from a collaborator. Mean ± SEM. t-test, *P < 0.05, **P < 0.01, ***P < 0.001.

Fig.3 IMQ induced Psoriasis model in hIL17A/hIL17F mice.?

At the study endpoint, back skin samples were harvested and stained with H&E. Representative H&E staining images of the back skin from mice and histological changes were quantified using Baker system.? Results indicated that Bimekizumab significantly reduced skin lesions in IMQ induced Psoriasis model in hIL17A/hIL17F mice (n=6).?

Test article 1 and test article 2 are from a collaborator. Mean ± SEM. t-test, ***P < 0.001.

Fig.4 IMQ induced Psoriasis model in hIL17A/hIL17F mice.?

At the study endpoint, back skin samples were harvested and hIL17F was tested by qPCR. Results indicated that Bimekizumab significantly reduced hIL17F expression level in IMQ induced Psoriasis model in hIL17A/hIL17F mice(n=6).?

Test article 1 and test article 2 are from a collaborator. Mean ± SEM. t-test, *P < 0.05.

IMQ誘導(dǎo)的Balb/c小鼠銀屑病模型及藥效評(píng)價(jià)

Fig.1 IMQ induced Psoriasis model in Balb/c. (A) body weight and (B) body weight change. *P<0.05,?**P<0.01,?***P<0.001 vs G2.

Fig.2 IMQ induced Psoriasis model in Balb/c. (A) ear thickness (B) skin thickness (C) cumulative score of PASI.?***P<0.001,?*P<0.05?vs G2.

Fig.3 IMQ induced Psoriasis model in Balb/c. (A) erythema score, (B) skin thickness score and (C) scabby score.?***P<0.001,?**P<0.01,?*P<0.05?vs G2.

Fig.4 IMQ induced Psoriasis model in Balb/c. (A) spleen weight, (B) spleen index, (C) spleen image and (D) dorsal image on day3. ***P<0.001?vs G2.

Fig.5 IMQ induced Psoriasis model in Balb/c. (A) serum TNF-α, (B) serum IL-23 and (C) serum IL-17A.?***P<0.001,??*P<0.05?vs G2.

Fig.6 IMQ induced Psoriasis model in Balb/c.?(A) Tnf-α (B) Il-23 (C) Il-17 mRNA expression of skin. (n=5). ***P<0.001,?**P<0.01?vs G2.

Fig.7 IMQ induced Psoriasis model in Balb/c. (A) Pathological Score (B) Epidermis thickness (C) typical pathology image. ****P<0.001,?**P<0.01?vs G2.