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哮喘疾病模型

疾病簡介

哮喘（asthma）是一種由多種細胞（如嗜酸性粒細胞、肥大細胞、T淋巴細胞等）及細胞組分參與的慢性氣道炎癥性疾病，具有異質(zhì)性和氣道高反應(yīng)性特征。其核心病理表現(xiàn)為氣道炎癥、氣道重塑及可變性氣流受限，臨床以反復發(fā)作的喘息、胸悶、咳嗽等癥狀為主，常在夜間或凌晨加重，多數(shù)患者可經(jīng)治療緩解。

疾病模型

優(yōu)質(zhì)的哮喘疾病模型是藥物評價的良好工具，常用的造模方式是采用屋塵螨提取物（house dust mite，HDM）、卵清蛋白（ovalbumin，OVA）等構(gòu)建小鼠哮喘模型。南模生物炎癥/自身免疫疾病評價平臺自主研發(fā)了多種哮喘小鼠模型，在不同品系（C57BL/6，hIL4/hIL4R mice，BALB/c 等）中進行了驗證，可用于哮喘治療藥物的藥效評價。

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Fig.1 OVA induced Balb/c mice asthma model. (A) Body weight (B) Body weight change. (*P<0.05, **P<0.01 Vs Group2)

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Fig.2 OVA induced Balb/c mice asthma model. (A) Inflammatory cell number in BALF. (B) Eosinophils in BALF. (C) Eosinophils percentage in inflammatory cell. (D) Serum total IgE concentration.

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Fig.3 OVA induced asthma model in BALB/c mice. (A) Lung H&E and PAS stain(B) Inflammatory cell infiltration score (C) Bronchial score.

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Fig.1 Body weight of HDM induced hIL4/hIL4R mice asthma model (n=6, Data are presented as Mean and ± SEM).

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Fig.2 HDM induced hIL4/hIL4R mice asthma model. (A) Inflammatory cell number in BALF. (B) Eosinophils in BALF. (C) Eosinophils percentage in inflammatory cell. (D) Serum total IgE concentration. (n=6, Data are presented as Mean and ± SEM.)?

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Fig.3 HDM induced hIL4/hIL4R mice asthma model. (A) hIL-4 mRNA expression level. (B) mIL-8 mRNA expression level. (C) mIL-13 mRNA expression level. (D) mIL-6 mRNA expression level. (E) mIL-17a mRNA expression level.

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Fig.4 HDM induced hIL-4/hIL-4R mice asthma model. (A) Representative images of H&E staining. (B) Pathology score results. (n=6, Data are presented as Mean and ± SEM.) Magnification, ×5.

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Fig.5 HDM induced hIL-4/hIL-4R mice asthma model. (A) Representative images of PAS staining. (B)mucus score. (n=6, Data are presented as Mean and ± SEM.) Magnification, ×10.

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