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特應(yīng)性皮炎疾病模型

疾病簡(jiǎn)介

特應(yīng)性皮炎（atopic dermatitis, AD）是一種以皮膚持續(xù)性瘙癢為特征的慢性、復(fù)發(fā)性的炎癥性皮膚病。它通常發(fā)生在兒童和青少年中，但也可能在成年人中出現(xiàn)。特應(yīng)性皮炎的發(fā)病原因復(fù)雜，可能與遺傳、環(huán)境、免疫等多種因素有關(guān)。

疾病模型

南模生物長(zhǎng)期致力于自身免疫性疾病相關(guān)研究，利用奧沙唑酮（Oxazolone，OXA）和2,4-二硝基氟苯（2，4-dinitrofluorobenzene，DNFB）等開發(fā)了多種特應(yīng)性皮炎小鼠模型，為相關(guān)藥物的藥效評(píng)估和安全性評(píng)價(jià)提供了強(qiáng)有力的工具。

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Fig.1 OXA induced AD model in hIL4/hIL4R mice. (A) body weight (B) body weight change.

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Fig.2 OXA induced AD model in hIL4/hIL4R mice. (A) gross observation on Day 21? (B) ear thickness (C) clinical score of skin.

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Fig.3 OXA induced AD model in hIL4/hIL4R mice. (A) serum IgE (B) spleen weight.

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Fig.4 OXA induced AD model in hIL4/hIL4R mice. (A) Pathology photos (B) Pathology score.

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Fig.1 Body weight of hIL4/hIL4Ra mice treated with dupilumab. *P<0.05.

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Fig.2 Dupilumab ameliorate overall atopic dermatitis activity in DNFB-induced AD Model. *P<0.05, **P<0.01, ***P<0.001.

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Fig.3 Dupilumab treatment significantly reduced IgE levels in serum and scratching times.?(A) day10 serum IgE (B) day16 serum IgE (C) scratch times on Day 12 (D) scratch times on Day 14. *P<0.05, **P<0.01, ***P<0.001.

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Fig.4 Dupilumab significantly mitigates inflammatory cell infiltration in lesioned skin on day 14. (A) dorsal image on day14; (B) Representative pathology images; (C) Inflammatory cell infiltration score; (D) neutrophils score; (E) eosinophils score; (F) epidermis thickness; (G) dermis thickness.?*P<0.05, **P<0.01, ***P<0.001.

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