hHLA-DPA1*03: 01

品系全名

C57BL/6Smoc-H2-Aaem1（hHLA-DPA1*03: 01）/Smoc

目錄號(hào)

NM-HU-210009

品系狀態(tài)

活體

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基因信息

基因名
H2-Aa

基因曾用名

Ia1; H2Aa; Ia-1; H-2Aa; Aalpha; IAalpha; I-Aalpha

NCBI ID

MGI ID

Ensembl ID

Pubmed

人類(lèi)同源基因

HLA-DQA1

品系描述

通過(guò)同源重組，將小鼠H2-Aa 基因進(jìn)行人源化修飾。
應(yīng)用領(lǐng)域：免疫治療；藥物篩選

驗(yàn)證數(shù)據(jù)

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Fig.1 Detection of HLA-DPA1 expression in large Intestine by RT-PCR.?Wild type:? one band at 429 bp with primers F1/R1 (mHla-dpa1); Homozygous: one band at 256 bp with primers F2/R2 (hHLA-DPA1). Abbr. M, DNA marker; HO, homozygous; WT, wild type.

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Fig2. Expression characterization of hHLA-DP on human PBMC.

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Fig3. Expression characterization of HLA-DPA1*03:01 on DCs in Blood in HLA-DPA1*03:01 KI mice.?Note: The anti-hMHC II antibody has been reported to react with a shared epitope of HLA-DR, HLA-DP, and HLA-DQ. The anti-mMHC II antibody reacts with a polymorphic determinant shared by the I-Ab, I-Ad, I-Aq, I-Ed, and I-Ek?MHC class II alloantigens from mice carrying H-2p,r,q,b,d,u?haplotypes.

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