hIL21R
品系全名
C57BL/6Smoc-Il21rtm1(hIL21R)Smoc
目錄號
NM-HU-210031
品系狀態(tài) 胚胎凍存
基因信息
基因名
IL21R
品系描述
利用ES細胞打靶方式，將小鼠Il21r基因全部或者部分替換為人源IL21R。從而表達人或人鼠嵌合IL21R蛋白，取代小鼠內源Il21r蛋白的表達。
應用領域：免疫治療；藥物篩選
*使用本品系發(fā)表的文獻需注明: hIL21R mice (Cat. NO. NM-HU-210031) were purchased from Shanghai Model Organisms Center, Inc..
驗證數(shù)據(jù)
Fig.1 Detection of IL21R expression in spleen and thymus by RT-PCR in hPD-1/hIL21R dKI mice?which were generated by crossing hIL21R(NM-HU-210031) with hPD-1(NM-HU-00015).
Wild type: only one band at 189 bp with primers F1/R1(mIl21r);
Homozygous: only one band at 177 bp with primers F2/R2(hIL21R).
Abbr. M, DNA marker; HO, homozygous; WT, wild type.
Fig.2?Detection of hIL21R expression in activated splenocyte in WT C57BL/6 and HO hPD-1/hIL21R dKI?mice?which were generated by crossing?hIL21R(NM-HU-210031)?with?hPD-1(NM-HU-00015).
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