通過(guò)同源重組，將小鼠Il15基因進(jìn)行人源化修飾。

Human IL15 expression analysis

Fig 1. Human IL15 expression analysis in homozygous NVG-hIL15 mice by ELISA.?

Fig 2. Humanized immune reconstitution levels and body weight growth curves in huPBMC-NVG-hIL15 mice.

Fig 3. Humanized immune reconstitution levels in huPBNK-NVG-hIL15 mice.

Fig 4. Efficacy evaluation of CD20-targeting antibody using Raji huPBNK model.

Fig 5. Functional protein detection in NK cells in the presence of anti-hCD20 antibody drug using Raji huPBNK model.

Fig 6. ADCC efficacy research in vitro using huPBNK model.

Fig 7. Body weight growth curves in γδT-NVG-hIL15 mice.

Fig 8. Survial rates in γδT-NVG-hIL15 mice.

Fig 9. Humanized immune reconstitution levels in γδT-NVG-hIL15 mice.

Fig 10. Humanized immune reconstitution levels in huHSC-NVG-hIL15 mice. A. hCD45⁺ cell and mCD45⁺ cell in PB. B. hCD3⁺, hCD19⁺, hCD56⁺, hCD33⁺, hCD33⁺hCD14⁺, hCD33⁺ hCD66b⁺ cell in hCD45⁺ cell.?