hCD3EDG
品系全名
C57BL/6Smoc-Cd3etm1(hCD3E)Cd3dtm1(hCD3D)Cd3gtm1(hCD3G)Smoc
目錄號
NM-HU-220120
品系狀態(tài)
活體
品系描述
驗(yàn)證數(shù)據(jù)
Fig.1 Detection of?human CD3E,CD3D,CD3G on T cell surface in HO hCD3EDG mice.
Fig.2 Lymphocyte Lineage Characterization in Blood in Homozygous hCD3EDG Mice.
Fig.3?In vivo?AICD and irAE Assessment of Bispecific T Cell Engager Antibodies in Homzygous hCD3EDG Mice.
Homozygous hCD3EDG mice were engrafted with MC38-hEpCAM to evaluate the AICD and irAE of OKT3 and anti-CD3×EpCAM bispecific antibody?in vivo.
Fig.4?In Vivo Response with Bispecific T Cell Engager Antibodies in Homozygous hCD3EDG Mice.
Homozygous hCD3EDG mice were engrafted with MC38-hCLDN18.2 to eveluate the in vivo efficacy of anti-CD3×Claudin18.2 bispecific antibody.
Fig.5?In vivo AICD and irAE Assessment of CD3 Bispecific Antibody in?homozygous?hCD3EDG Mice.
The anti-tumor response of anti-mPD-1 was evaluated in homozygous hCD3EDG mice bearing MC38 syngeneic tumor model.
Fig.6?In vivo AICD and irAE Assessment of CD3 Bispecific Antibody with Homozgyous hCD3EDG Mice.
Homozygous hCD3EDG mice were engrafted with MC38-hEpCAM to eveluate the AICD and irAE of anti-CD3×EpCAM bispecific antibody at low and high dose levels in vivo.
Fig.7?In Vivo Response with Bispecific T Cell Engager Antibodies.
你也可能感興趣
Cre-ERT2在無Tamoxifen誘導(dǎo)的情況下，在細(xì)胞質(zhì)內(nèi)處于無活性狀態(tài)；當(dāng)Tamoxifen誘導(dǎo)后，Tamoxifen的代謝產(chǎn)物4-OHT（雌激素類似物）與ERT結(jié)合，可使Cre-ERT2進(jìn)核發(fā)揮Cre重組酶活性。
查看常見的基因工程小鼠可以分為兩種命名方式，包括基因定點(diǎn)修飾的小鼠命名，比如：敲除、敲入、點(diǎn)突變等等，和隨機(jī)轉(zhuǎn)基因的小鼠命名。
查看
