hCD3EDG

品系全名

C57BL/6Smoc-Cd3etm1(hCD3E)Cd3dtm1(hCD3D)Cd3gtm1(hCD3G)Smoc

目錄號

NM-HU-220120

品系狀態(tài)

活體

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品系描述

通過同源重組，對小鼠Cd3e/Cd3d/Cd3g基因進行人源化修飾，該小鼠簡稱為hCD3EDG。

驗證數(shù)據(jù)

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Fig.1 Detection of?human CD3E,CD3D,CD3G on T cell surface in HO hCD3EDG mice.

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Fig.2 Lymphocyte Lineage Characterization in Blood in Homozygous hCD3EDG Mice.

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Fig.3?In vivo?AICD and irAE Assessment of Bispecific T Cell Engager Antibodies in Homzygous hCD3EDG Mice.

Homozygous hCD3EDG mice were engrafted with MC38-hEpCAM to evaluate the AICD and irAE of OKT3 and anti-CD3×EpCAM bispecific antibody?in vivo.

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Fig.4?In Vivo Response with Bispecific T Cell Engager Antibodies in Homozygous hCD3EDG Mice.

Homozygous hCD3EDG mice were engrafted with MC38-hCLDN18.2 to eveluate the in vivo efficacy of anti-CD3×Claudin18.2 bispecific antibody.

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Fig.5?In vivo AICD and irAE Assessment of CD3 Bispecific Antibody in?homozygous?hCD3EDG Mice.

The anti-tumor response of anti-mPD-1 was evaluated in homozygous hCD3EDG mice bearing MC38 syngeneic tumor model.image.png

Fig.6?In vivo AICD and irAE Assessment of CD3 Bispecific Antibody with Homozgyous hCD3EDG Mice.

Homozygous hCD3EDG mice were engrafted with MC38-hEpCAM to eveluate the AICD and irAE of anti-CD3×EpCAM bispecific antibody at low and high dose levels in vivo.

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Fig.7?In Vivo Response with Bispecific T Cell Engager Antibodies.

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