Fig.1 Detection of hBAFF expression in serum by ELISA.?

Abbr.? WT, wild type; HE, heterozygous.

Fig.2 Detection of immune phenotype in WT C57BL/6 and HE H11-pAlb-hBAFF mice.

Fig.3?Detection of phenotype in Peripheral blood in WT C57BL/6 and HE H11-pAlb-hBAFF mice.

Fig.4 Detection of phenotype in Spleen in WT C57BL/6 and HE H11-pAlb-hBAFF mice.

Fig.5?Detection of phenotype in Lymph node in WT C57BL/6 and HE H11-pAlb-hBAFF mice.

Fig.6?Detection of phenotype in Bone marrow in WT C57BL/6 and HE H11-pAlb-hBAFF mice.

Fig.7?Body weight of H11-pAlb-hBAFF mice at different time points.?

Fig.8?Tissue weights and photos of H11-pAlb-hBAFF mice at different time points.

Enlarged spleen and Peyer's patches in H11-pAlb-hBAFF mice.

Fig.9 Detect the dsDNA levels in the blood of H11-pAlb-hBAFF mice. (n=5~7/group, Kit information: Apha Diagnostic, 5120)

Fig.10 Expression characterization of mIgA (A), mIgE (B), mIgM (C) and mIgG (D) in HE H11-pAlb-hBAFF mice by ELISA.

Fig.11?Urinary Biochemical Analysis of H11-pAlb-hBAFF mice (n=5~7/group).

Fig.12 H&E Staining and pathological analysis results of Kidney.

Green arrow: mild edema of renal tubular epithelial cells; Blue arrow: mild vacuolar degeneration of renal tubular epithelial cells; Light-green arrow: frequent mesangial matrix proliferation in glomeruli.