H11-pAlb-hBAFF

品系全名

C57BL/6Smoc-Igs2em1(pAlb-hBAFF-pA)Smoc

目錄號

NM-KI-232137

品系狀態(tài)

活體

導(dǎo)出PDF

基因信息

基因名

基因曾用名

H11，Hipp11，Iis2

NCBI ID

Null

MGI ID

Ensembl ID

Null

Pubmed

品系描述

將pAlb-hBAFF-pA插入到小鼠H11位點。

驗證數(shù)據(jù)

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Fig.1 Detection of hBAFF expression in serum by ELISA.?

Abbr.? WT, wild type; HE, heterozygous.

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Fig.2 Detection of immune phenotype in WT C57BL/6 and HE H11-pAlb-hBAFF mice.

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Fig.3?Detection of phenotype in Peripheral blood in WT C57BL/6 and HE H11-pAlb-hBAFF mice.

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Fig.4 Detection of phenotype in Spleen in WT C57BL/6 and HE H11-pAlb-hBAFF mice.

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Fig.5?Detection of phenotype in Lymph node in WT C57BL/6 and HE H11-pAlb-hBAFF mice.

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Fig.6?Detection of phenotype in Bone marrow in WT C57BL/6 and HE H11-pAlb-hBAFF mice.

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Fig.7?Body weight of H11-pAlb-hBAFF mice at different time points.?

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Fig.8?Tissue weights and photos of H11-pAlb-hBAFF mice at different time points.

Enlarged spleen and Peyer's patches in H11-pAlb-hBAFF mice.

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Fig.9 Detect the dsDNA levels in the blood of H11-pAlb-hBAFF mice. (n=5~7/group, Kit information: Apha Diagnostic, 5120)

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Fig.10 Expression characterization of mIgA (A), mIgE (B), mIgM (C) and mIgG (D) in HE H11-pAlb-hBAFF mice by ELISA.

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Fig.11?Urinary Biochemical Analysis of H11-pAlb-hBAFF mice (n=5~7/group).

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Fig.12 H&E Staining and pathological analysis results of Kidney.

Green arrow: mild edema of renal tubular epithelial cells; Blue arrow: mild vacuolar degeneration of renal tubular epithelial cells; Light-green arrow: frequent mesangial matrix proliferation in glomeruli.

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