Ly6g-2A-CreERT2
品系全名
C57BL/6Smoc-Ly6gem3(2A-CreERT2)Smoc
目錄號(hào)
NM-KI-200218
品系狀態(tài)
活體
基因信息
基因名
Ly6g
品系描述
驗(yàn)證數(shù)據(jù)
Fig1. Cre mediated recombination in spleen of Ly6gCreERT2/+;Rosa26tdTomato/+ mouse.
Fig2. Detection of tdTomato(red) in various tissues of Ly6gCreERT2/+;Rosa26tdTomato/+ mouse. Expression tissues include: spleen, colon,lung. A few cells expressed in testis, thymus. Tissues that unexpressed include brain, spinal cord, retina, heart, liver, stomach, salivary glands, brown fat, pituitary gland, kidney, pancreas, small intestine, muscle and epidermis. (8-weeks old, male) (For more detailed information please contact our technical advisor.)?
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Cre-ERT2在無(wú)Tamoxifen誘導(dǎo)的情況下,在細(xì)胞質(zhì)內(nèi)處于無(wú)活性狀態(tài);當(dāng)Tamoxifen誘導(dǎo)后,Tamoxifen的代謝產(chǎn)物4-OHT(雌激素類似物)與ERT結(jié)合,可使Cre-ERT2進(jìn)核發(fā)揮Cre重組酶活性。
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