Tert-CreERT2-2A-EGFP
品系全名
C57BL/6Smoc-Tertem1(CreERT2-2A-GFP-WPRE-PA)Smoc
目錄號(hào)
NM-KI-18037
品系狀態(tài)
精子凍存
基因信息
基因名
Tert
品系描述
驗(yàn)證數(shù)據(jù)
Fig1. CreERT2 mediated recombination in small intestine of TertCreERT2-EGFP/+;Rosa26tdTomato/+ mouse.
Fig2. Detection of EGFP(green) and tdTomato(red) in various tissues of TertCreERT2-EGFP/+;Rosa26tdTomato/+ mouse. Expression tissues include: small intestine, lung, liver, salivary gland, kidney, pancreas. A few cells expressed in brain, stomach, colon, spleen, skin, thymus, ovary. Tissues that unexpressed include eye, heart, brown fat. No significant EGFP positive signal was detected. (6.5-months old, female) (For more detailed information please contact our technical advisor.)?
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Cre-ERT2在無Tamoxifen誘導(dǎo)的情況下,在細(xì)胞質(zhì)內(nèi)處于無活性狀態(tài);當(dāng)Tamoxifen誘導(dǎo)后,Tamoxifen的代謝產(chǎn)物4-OHT(雌激素類似物)與ERT結(jié)合,可使Cre-ERT2進(jìn)核發(fā)揮Cre重組酶活性。
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