Vav1-2A-CreERT2
品系全名
C57BL/6Smoc-Vav1em1(2A-CreERT2-WPRE-pA)Smoc
目錄號(hào)
NM-KI-233229
品系狀態(tài)
活體
基因信息
基因名
Vav1
品系描述
驗(yàn)證數(shù)據(jù)
Fig1. Cre mediated recombination in spleen of Vav1CreERT2/+; Rosa26tdTomato/+ mouse.?
Fig2. Detection of tdTomato(red) in various tissues of Vav1CreERT2/+; Rosa26tdTomato/+ mouse. The tissues of double-positive mice were cryosectioned and directly examined, revealing expression in the following organs: spleen, thymus, spinal cord, lung, liver, stomach, salivary gland, brown fat, adrenal gland, kidney, pancreatic islet, small intestine, colon, testicular interstitium, skin, pituitary gland. A few cells expressed in heart, muscle. Non-expressed tissues included brain, retina. (43-days old, male) (For more detailed information please contact our technical advisor.)?
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Cre-ERT2在無Tamoxifen誘導(dǎo)的情況下,在細(xì)胞質(zhì)內(nèi)處于無活性狀態(tài);當(dāng)Tamoxifen誘導(dǎo)后,Tamoxifen的代謝產(chǎn)物4-OHT(雌激素類似物)與ERT結(jié)合,可使Cre-ERT2進(jìn)核發(fā)揮Cre重組酶活性。
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