Flt3-2A-CreERT2
品系全名
C57BL/6Smoc-Flt3em1(2A-CreERT2)Smoc
目錄號
NM-KI-231796
品系狀態(tài) 精子凍存
基因信息
基因名
Flt3
品系描述
驗證數(shù)據(jù)
Fig1. Cre mediated recombination in bone marrow of Flt3CreERT2/+;Rosa26tdTomato/+ mouse.??
Fig2. Detection of tdTomato(red) in various tissues of Flt3CreERT2/+;Rosa26tdTomato/+ mouse. Expression tissues include: lung, bone marrow, kidney, spleen and muscle. A few cells expressed in brain, liver, stomach, salivary gland, brown fat, adrenal gland, colon, testis, skin, thymus. Tissues that unexpressed include spinal cord, retina, heart, pancreas, small intestine and pituitary gland. (49-days old, male) (For more detailed information please contact our technical advisor.)
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Cre-ERT2在無Tamoxifen誘導的情況下,在細胞質(zhì)內(nèi)處于無活性狀態(tài);當Tamoxifen誘導后,Tamoxifen的代謝產(chǎn)物4-OHT(雌激素類似物)與ERT結合,可使Cre-ERT2進核發(fā)揮Cre重組酶活性。
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