Dhh-CreERT2
品系全名
C57BL/6Smoc-Dhhem(Kozak-CreERT2-WPRE-pA)1Smoc
目錄號(hào)
NM-KI-225050
品系狀態(tài)
精子凍存
基因信息
基因名
Dhh
品系描述
驗(yàn)證數(shù)據(jù)
Fig1. CreERT2 mediated recombination in reproduction of DhhCreERT2/+;Rosa26 tdTomato/+ mice.
Fig2. CreERT2 mediated recombination in sciatic nerve of DhhCreERT2/+;Rosa26?tdTomato/+?mice.
Fig3. Detection of tdTomato(red) in various tissues of DhhCreERT2/+;Rosa26 tdTomato/+ mice. The organization of tdTomato expression: reproduction, large intestine, small intestine, sciatic nerve, thymus.Tissues that do not express tdTomato: Brain, spleen, Heart, lungs, kidneys, brown fat, skin. (52-days old, male) (For more detailed information please contact our technical advisor.)?
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Cre-ERT2在無(wú)Tamoxifen誘導(dǎo)的情況下,在細(xì)胞質(zhì)內(nèi)處于無(wú)活性狀態(tài);當(dāng)Tamoxifen誘導(dǎo)后,Tamoxifen的代謝產(chǎn)物4-OHT(雌激素類(lèi)似物)與ERT結(jié)合,可使Cre-ERT2進(jìn)核發(fā)揮Cre重組酶活性。
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