Cspg4-CreERT2-2A
品系全名
C57BL/6Smoc-Cspg4em(CreERT2-P2A)1Smoc
目錄號
NM-KI-225033
品系狀態(tài)
活體
基因信息
基因名
Cspg4
品系描述
驗證數(shù)據(jù)
Fig 1. Cre-mediated recombination in Cortex of Cspg4CreERT2/+; Rosa26tdTomato/+ mice.
Fig 2. Detection of tdTomato (red) in various tissues of Cspg4CreERT2/+; Rosa26tdTomato/+ mice. Expression tissues include: brain, spinal cord, cornea, lung, liver, brown fat, kidney, small intestine, colon, uterus, muscle and skin. A few cells expressed in heart, stomach, adrenal gland, pancreas, spleen, ovary and thymus. Tissues that unexpressed include salivary glands. (5-week old, female) (For more detailed information please contact our technical advisor.)?
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Cre-ERT2在無Tamoxifen誘導(dǎo)的情況下,在細(xì)胞質(zhì)內(nèi)處于無活性狀態(tài);當(dāng)Tamoxifen誘導(dǎo)后,Tamoxifen的代謝產(chǎn)物4-OHT(雌激素類似物)與ERT結(jié)合,可使Cre-ERT2進(jìn)核發(fā)揮Cre重組酶活性。
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