Ins2-CreERT2
品系全名
C57BL/6Smoc-Ins2em(CreERT2)1Smoc
目錄號(hào)
NM-KI-225022
品系狀態(tài)
精子凍存
基因信息
基因名
Ins2
品系描述
驗(yàn)證數(shù)據(jù)
Fig 1. CreERT2-mediated recombination in pancreas of Ins2CreERT2/+; Rosa26tdTomato/+?mice.
Fig 2. Detection of tdTomato(red) in various tissues of Ins2CreERT2/+; Rosa26tdTomato/+?mice.?Expression tissues include: pancreas, brain(choroid plexus). A few cells expressed in lung, stomach, small intestine, testis, thymus. Tissues that unexpressed include spinal cord, retina, liver, heart, salivary glands, brown fat, adrenal gland,? kidneys, colon, spleen, muscle, skin. (7.3-week old, male) (For more detailed information please contact our technical advisor.)?
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Cre-ERT2在無(wú)Tamoxifen誘導(dǎo)的情況下，在細(xì)胞質(zhì)內(nèi)處于無(wú)活性狀態(tài)；當(dāng)Tamoxifen誘導(dǎo)后，Tamoxifen的代謝產(chǎn)物4-OHT（雌激素類似物）與ERT結(jié)合，可使Cre-ERT2進(jìn)核發(fā)揮Cre重組酶活性。
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