Cyp19a1-IRES-Cre
品系全名
C57BL/6Smoc-Cyp19a1em(IRES-Cre)Smoc
目錄號
NM-KI-215089
品系狀態(tài) 精子凍存
基因信息
基因名
Cyp19a1
品系描述
驗證數(shù)據(jù)
Fig 1. Cre-mediated recombination in ovary of Cyp19a1Cre/+; Rosa26tdTomato/+?mice.
Fig 2. Cre-mediated recombination in testis of Cyp19a1Cre/+; Rosa26tdTomato/+?mice.
Fig 3. Cre-mediated recombination in brain of Cyp19a1Cre/+; Rosa26tdTomato/+?female mice.
Fig 4. Cre-mediated recombination in brain of Cyp19a1Cre/+; Rosa26tdTomato/+?male mice.
Fig 5. Detection of tdTomato (red) in various tissues of Cyp19a1Cre/+; Rosa26tdTomato/+?female mice.?
Fig 6. Detection of tdTomato (red) in various tissues of Cyp19a1Cre/+; Rosa26tdTomato/+?male mice.?Expression tissues include: brain, cornea, heart, lungs, liver, stomach, salivary glands, adrenal glands, kidneys, pancreas, small intestine, colon, spleen, testis, thymus. A few cells expressed in brown fat, spinal cord, muscle, skin. (12-week old, male) (For more detailed information please contact our technical advisor.)?
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Cre-ERT2在無Tamoxifen誘導的情況下,在細胞質(zhì)內(nèi)處于無活性狀態(tài);當Tamoxifen誘導后,Tamoxifen的代謝產(chǎn)物4-OHT(雌激素類似物)與ERT結(jié)合,可使Cre-ERT2進核發(fā)揮Cre重組酶活性。
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