Avil-2A-CreERT2
品系全名
C57BL/6Smoc-Avilem1(2A-CreERT2)Smoc
目錄號
NM-KI-215035
品系狀態(tài) 精子凍存
基因信息
基因名
Avil
品系描述
將2A-CreERT2插入到小鼠Avil基因終止密碼子處。
*使用本品系發(fā)表的文獻需注明: Avil-2A-CreERT2 mice (Cat. NO. NM-KI-215035) were purchased from Shanghai Model Organisms Center, Inc..
驗證數(shù)據(jù)
Fig1. Avil-CreERT2/CAG-LSL-tdTomato mice were injected intraperitoneally with tamoxifen at a dose of 120 mg/kg, administered 3 times, every other day. Seven days after the last injection, the trigeminal ganglia of mice were harvested, the tdTomato signal was detected after tissue sectioning, and the NeuN signal was detected by immunofluorescence.
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Tamoxifen誘導Cre-ERT2小鼠 使用指南
Cre-ERT2在無Tamoxifen誘導的情況下，在細胞質(zhì)內(nèi)處于無活性狀態(tài)；當Tamoxifen誘導后，Tamoxifen的代謝產(chǎn)物4-OHT（雌激素類似物）與ERT結(jié)合，可使Cre-ERT2進核發(fā)揮Cre重組酶活性。
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