Tlr5-CreERT2
品系全名
C57BL/6Smoc-Tlr5em1(CreERT2)Smoc
目錄號
NM-KI-215033
品系狀態(tài) 精子凍存
基因信息
基因名
Avil
品系描述
將CreERT2插入到小鼠Tlr5基因終止密碼子處。
*使用本品系發(fā)表的文獻需注明: Tlr5-CreERT2 mice (Cat. NO. NM-KI-215033) were purchased from Shanghai Model Organisms Center, Inc..
驗證數(shù)據(jù)
Fig1.?Tlr5-CreERT2/CAG-LSL-tdTomato mice were injected intraperitoneally with tamoxifen at a dose of 120 mg/kg, administered 3 times, every other day.?Seven days after the last injection, the Dorsal Root Ganglion (DRG) of mice were harvested, the tdTomato signal was detected after tissue sectioning.
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Tamoxifen誘導Cre-ERT2小鼠 使用指南
Cre-ERT2在無Tamoxifen誘導的情況下，在細胞質內處于無活性狀態(tài)；當Tamoxifen誘導后，Tamoxifen的代謝產物4-OHT（雌激素類似物）與ERT結合，可使Cre-ERT2進核發(fā)揮Cre重組酶活性。
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