Mrc1-2A-CreERT2
品系全名
C57BL/6Smoc-Mrc1em2(2A-CreERT2)Smoc
目錄號(hào)
NM-KI-220031
品系狀態(tài)
活體
基因信息
基因名
Mrc1
品系描述
驗(yàn)證數(shù)據(jù)
Fig 1. Cre-mediated recombination in liver of Mrc1CreERT2/+; Rosa26tdTomato/+ mice.
Fig 2. Detection of tdTomato (red) in various tissues of Mrc1CreERT2/+; Rosa26tdTomato/+?mice.?Expression tissues include: liver. A few cells expressed in large intestine, spleen, skin, thymus. Tissues that unexpressed include brain, spinal cord, retina, heart, lung, stomach, salivary glands, brown fat, pituitary gland, kidney, pancreas, small intestine, testis, muscle, adrenal gland. (4.5-month old, male) (For more detailed information please contact our technical advisor.)?
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Cre-ERT2在無(wú)Tamoxifen誘導(dǎo)的情況下,在細(xì)胞質(zhì)內(nèi)處于無(wú)活性狀態(tài);當(dāng)Tamoxifen誘導(dǎo)后,Tamoxifen的代謝產(chǎn)物4-OHT(雌激素類(lèi)似物)與ERT結(jié)合,可使Cre-ERT2進(jìn)核發(fā)揮Cre重組酶活性。
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