Pah-KO
品系全名
C57BL/6Smoc-Pahem1Smoc
目錄號
NM-KO-2110565
品系狀態(tài) 活體
基因信息
基因名
Pah
品系描述
疾病預(yù)測
Phenylketonuria
驗證數(shù)據(jù)
Fig.1 Detection of Pah expression in liver and kidney of 16-week-old male WT and Pah-KO mice by RT-PCR.?
Wild type: one band at 193 bp with primers F1/R1(m Pah) and one band at 178 bp with primers F/R(mGapdh).
Homozygous: no band at 193 bp with primers F1/R1(m Pah) and one band at 178 bp with primers F/R(mGapdh).
Abbr. M, DNA marker; HO, homozygous; WT, wild type.
Fig.2 Detection of Pah mRNA expression in liver and kidney of 16-week-old male WT and Pah-KO mice by crop.?
Abbr. M, DNA marker; HO, homozygous; WT, wild type.
Fig.3 Detection of mouse PAH expression of 16-week-old male WT and Pah-KO mice by WB.?
Abbr. M, marker; WT, wild type; HO, Homozygous.
Fig.4 Characterization of WT C57BL/6 and Pah-KO mice.?
(A) The Pah-KO mice showed lower body weights than the WT mice (n=20/group). (B) Summary of blood Phe at various timepoints is shown (n=20/group). (C) Summary of blood Tyr at various timepoints is shown (n=20/group). Note: Data from the third party.
Fig.5 Hair coat color in WT C57BL/6 and Pah-KO mice.?
Hair coat of the Pah-KO mouse is light brown whereas it is dark brown for the WT C57BL/6 mouse.
Note: Data from the third party.
Fig.6 Brain weight analysis of 16-17-week-old WT and HO Pah-KO mice. (n=3, ?Mean ± SEM. t-test, **p < 0.01).
Brain weight analysis showed that the brain weight of Pah-KO mice is significantly reduced.?
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