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代謝類藥物靶點人源化模型

代謝類藥物靶點人源化小鼠模型是通過基因編輯技術(shù)將人類的代謝相關(guān)基因或蛋白靶點插入到小鼠基因組中的小鼠模型。這類模型在代謝類藥物的研發(fā)和研究中具有重要應(yīng)用價值。
代謝類藥物靶點人源化模型精選
代謝類藥物靶點人源化小鼠資源庫
目錄號 品系簡稱 品系名稱 品系狀態(tài)
NM-KI-215053 R26-CAG-LSL-hAR-IRES-EGFP C57BL/6Smoc-Gt(ROSA)26Sorem1(R26-CAG-Loxp-Stop-Loxp-hAR-IRES-EGFP-WPRE-pA)Smoc 精子凍存
NM-KI-190127 R26-CAG-LSL-hBCR/ABL C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-loxp-STOP-loxp-BCR-ABL-IRES-Luciferase-2A-tdTomato-WPRE-polyA)Smoc 胚胎凍存
NM-KI-190107 R26-CAG-LSL-hETV6/NTRK3-IRES-Luc-2A-tdTomato C57BL/6Smoc-Gt(ROSA)26Sorem1(SA-polyA-CAG-LSL-ETV6-NTRK3-IRES-luc-2A-tdTomato-WPRE-polyA)Smoc 精子凍存
NM-KI-190074 R26-CAG-LSL-hIDH1*R132H-IRES-Luc-2A-tdTomato C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-IDH1(R132H)-IRES-Luciferase-2A-tdTomato)Smoc 胚胎凍存
NM-KI-190114 R26-CAG-LSL-hMLL-AF9-IRES-Luc-2A-tdTomato C57BL/6Smoc-Gt(ROSA)26Sorem1(SA-FRT-2xpA-CAG-FRT-loxp-STOP-loxp-MLL-AF9-IRES-Luciferase-2A-tdTomato -WPRE-polyA)Smoc 胚胎凍存
NM-KI-200013 R26-CAG-LSL-hPNPLA3-I148M-EGFP C57BL/6Smoc-Gt(ROSA)26Sorem1(SA-Frt-2xpolyA-CAG-Frt-LSL-hPNPLA3 I148M-IRES-GFP-wpre-polyA)Smoc 活體
NM-KI-200263 R26-CAG-LSL-hSOD1*G94A-IRES-EGFP C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-FRT-LSL- SOD1(G94A)-IRES-EGFP-WPRE-pA)Smoc 精子凍存
NM-KI-18035 R26-CAG-LSL-hTERT-IRES-Luc-2A-EGFP C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-V5-TERT-IRES-Luciferase-2A-EGFP-WPRE-pA)Smoc 胚胎凍存
NM-KI-200017 R26-CAG-LSL-hTM6SF2*E167K-EGFP C57BL/6Smoc-Gt(ROSA)26Sorem1(SA-Frt-2xpolyA-CAG-Frt-LSL-TM6SF2-IRES-GFP-WPRE-PA)Smoc 胚胎凍存
NM-KI-18032 R26-pAPOE-hCYP3A4(FVB) FVB-Gt(ROSA)26Sorem1(pAPOE-CYP3A4)Smoc 胚胎凍存
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