hDMPK
品系全名
C57BL/6Smoc-Dmpktm1(hDMPK)Smoc
目錄號
NM-HU-225084
品系狀態(tài) 胚胎凍存
基因信息
基因名
Dmpk
品系描述
利用同源重組，將小鼠Dmpk基因進行人源化修飾。
應用領域：核酸藥物人源化
*使用本品系發(fā)表的文獻需注明: hDMPK mice (Cat. NO. NM-HU-225084) were purchased from Shanghai Model Organisms Center, Inc..
驗證數(shù)據(jù)
Fig.1 Detection of DMPK expression in heart by RT-PCR.?
Wild type: only one band at 259 bp with primers F1/R1(mDmpk);
Homozygous: only one band at 324 bp with primers F2/R2(hDMPK).
Abbr. M, DNA marker; HO, homozygous; WT, wild type.
Fig.2 Detection of human DMPK expression in hDMPK knockin mice by WB.?
Abbr. M, marker; WT, wild type; HO, Homozygous; PC, hela cells.
Note. The anti-human DMPK antibody cross-reacted with mouse DMPK and humanized DMPK. Arrow indicates expected molecular weight and asterisk indicates a nonspecific band.
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