hPCSK9

品系全名

C57BL/6Smoc-Pcsk9em2(hPCSK9)/Smoc

目錄號(hào)

NM-HU-00075

品系狀態(tài)

活體

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基因信息

基因名
Pcsk9

基因曾用名

AI415265; AI747682; FH3; HCHOLA3; Narc1; PC9

NCBI ID

MGI ID

Ensembl ID

Pubmed

人類同源基因

PCSK9

品系描述

通過同源重組，將小鼠Pcsk9基因進(jìn)行人源化修飾。
應(yīng)用領(lǐng)域：免疫治療；腫瘤研究；藥物篩選

驗(yàn)證數(shù)據(jù)

hPCSK9.png

Fig.1 Expression of PCSK9 in the serum of humanized PCSK9 homozygous mice is detected by Elisa. (a) The expression of human PCSK9 can be detected in the serum collected from homozygous mice. (b) The expression of mouse PCSK9 can not be detected in the serum collected from homozygous mice.

image.png

Fig.2 Detection of the blood lipid index of (A) TG, (B) TC, (C) HDL-C and (D) LDL-C in chow diet-fed WT mice and HO hPCSK9 mice before treatment. (n=7-8, 6-week-old male mice).

Abbr. WT, wild type; HO, Homozygous; CD, chow diet.

image.png

Fig.3 Body weight in chow diet-fed and Evolocumab-treated HO hPCSK9 knockin mice (8 male mice in each group).

Abbr. HO, Homozygous; CD, chow diet.

image.png

Fig.4 Detection of the blood lipid index of (A) TG, (B) T-CHO, (C) HDL-C and (D) LDL-C in chow diet-fed and Evolocumab-treated HO hPCSK9 knockin mice.?

Blood lipids level of hPCSK9 mice before and after dosing were detected. Data were all normalized to control (8 male mice in each group. Mean ± SEM. *p < 0.05 and **p < 0.01 in Evolocumab group under t-test versus control).

Abbr. HO, Homozygous; CD, chow diet.

image.png

Fig.5 Liver weight-to-body weight ratio in chow diet-fed HO hPCSK9 knockin mice after 35 days of dosing (8 male mice in each group).

Abbr. HO, Homozygous; CD, chow diet.

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