hGCGR

品系全名

C57BL/6Smoc-Gcgrem(hGCGR)Smoc

目錄號

NM-HU-215004

品系狀態(tài)

活體

導(dǎo)出PDF

基因信息

基因名
Cxcr5

品系描述

利用同源重組,將小鼠Gcgr進(jìn)行人源化修飾。
應(yīng)用領(lǐng)域:非胰島素依賴性Gcgr相關(guān)的高血糖素血癥和糖尿病

驗(yàn)證數(shù)據(jù)

image.png

Fig1. Detection of GCGR expression in liver by RT-PCR.?

Wild type: only one band at 589 bp with primers F1/R1(mGcgr);

Homozygous: only one band at 501 bp with primers F2/R2(hGCGR).

Abbr. M, DNA marker; HO, homozygous; WT, wild type.

image.png

Fig2. Detection of hGCGR expression in hGCGR Mice by WB.?

Abbr. M,marker; HO, homozygous; WT, wild type.

Note. The anti-human GCGR Antibody cross-reacted with mouse GCGR and humanized GCGR.

image.png

Fig3. Detection of hGCGR expression in Kidney in hGCGR KI mice

Note. The anti-human GCGR antibody cross-reacted with mouse GCGR and humanized GCGR.

image.png

Fig4. Detection of hGCGR expression in Liver in hGCGR KI mice.

Note. The anti-human GCGR antibody cross-reacted with mouse GCGR and humanized GCGR.



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