hALB/hFCRN

品系全名

C57BL/6Smoc-Albem3(hALB)Fcgrtem2(hFCGRT)/Smoc

目錄號

NM-HU-200278

品系狀態(tài)

活體

導出PDF

基因信息

基因名

基因曾用名

Alb1， Alb-1， BCL002，F(xiàn)cRn

NCBI ID

MGI ID

87991，103017

Pubmed

人類同源基因

ALB，F(xiàn)CGR

品系描述

通過hALB(NM-HU-200003)與hFCRN(NM-HU-190070)小鼠交配獲得
應用領域：腫瘤研究；免疫治療；藥物篩選

驗證數(shù)據(jù)

image.png

Fig.1 Detection of hALB (A) and mALB (B) expression in serum by ELISA (n=3).?

Abbr. HO, homozygous; WT, wild type.image.png

Fig.2 Expression characterization of hFCRN in hALB/hFCRN dKI mice by Western blot. (Arrow indicates expected molecular weight and asterisk indicates a nonspecific band)??

image.png

Fig.3 In vivo PK profiles of TAA scfv-anti HSA VHH in hALB/hFCRN mice (female, 10-12weeks, n=3 mice/timepoint).

(In cooperation with the third party).

image.png

Fig.4 Blood concentration curves of test articles in C57BL/6 and hFcRn/hALB dKI mice. (In cooperation with the third party)?

image.png

Table 1 Noncompartmental Analysis (NAC) results of test articles in hFcRn/hALB dKI mice. (In cooperation with the third party)?

image.png

Fig.5 Fitting curves of blood concentration in C57BL/6 and hFcRn/hALB dKI mice. (In cooperation with the third party)?

你也可能感興趣

Tamoxifen誘導Cre-ERT2小鼠 使用指南

Cre-ERT2在無Tamoxifen誘導的情況下，在細胞質內處于無活性狀態(tài)；當Tamoxifen誘導后，Tamoxifen的代謝產物4-OHT（雌激素類似物）與ERT結合，可使Cre-ERT2進核發(fā)揮Cre重組酶活性。

查看
【小鼠大學問】基因工程小鼠的命名規(guī)則

常見的基因工程小鼠可以分為兩種命名方式，包括基因定點修飾的小鼠命名，比如：敲除、敲入、點突變等等，和隨機轉基因的小鼠命名。

查看