Mnx1-2A-CreERT2
品系全名
C57BL/6Smoc-Mnx1em1(2A-CreERT2-WPRE-polyA)Smoc
目錄號
NM-KI-200009
品系狀態(tài) 精子凍存
基因信息
基因名
Mnx1
品系描述
驗證數(shù)據(jù)
Fig1. CreERT2 mediated recombination in spinal cord of Mnx1CreERT2/+; Rosa26tdTomato/+ mouse.
Fig2. Detection of tdTomato(red) in various tissues of Mnx1CreERT2/+; Rosa26tdTomato/+?mouse.?Expression tissues include: spinal cord, heart, lungs, stomach, salivary gland, adrenal gland, pancreas, large intestine, small intestine, spleen, testis, muscle, thymus. Scattered cells were expressed in skin.Tissues with no expression: brain, eye, liver, brown adipose tissue, kidney. (7-weeks old, male) (For more detailed information please contact our technical advisor.)?
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Cre-ERT2在無Tamoxifen誘導的情況下,在細胞質內(nèi)處于無活性狀態(tài);當Tamoxifen誘導后,Tamoxifen的代謝產(chǎn)物4-OHT(雌激素類似物)與ERT結合,可使Cre-ERT2進核發(fā)揮Cre重組酶活性。
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