Atp4b-IRES-CreERT2
品系全名
C57BL/6Smoc-Atp4bem1(IRES-CreERT2-WPRE-pA)Smoc
目錄號(hào)
NM-KI-210118
品系狀態(tài)
精子凍存
基因信息
基因名
Atp4b
品系描述
驗(yàn)證數(shù)據(jù)
Fig1. CreERT2-mediated recombination in the stomach of Atp4bCreERT2/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected?in the stomach of Atp4bCreERT2/+; Rosa26tdTomato/+ mouse after tamoxifen treatment. Some leakiness was detected prior to tamoxifen exposure.
Fig2.?Detection of tdTomato (red) in various tissues of? Atp4bCreERT2/+; Rosa26tdTomato/+ mice after tamoxifen treatment. Tdtomato was expressed in the glandular stomach. Tdtomato can also be detected in the pituitary, thymus, salivary glands, brown adipose tissue, spleen, pancreas, and muscle. Some leakiness was detected prior to tamoxifen exposure. TdTomato expression can not be detected in the brain, liver, lung, large intestine, small intestine, kidney or skin.
你也可能感興趣
Cre-ERT2在無(wú)Tamoxifen誘導(dǎo)的情況下,在細(xì)胞質(zhì)內(nèi)處于無(wú)活性狀態(tài);當(dāng)Tamoxifen誘導(dǎo)后,Tamoxifen的代謝產(chǎn)物4-OHT(雌激素類(lèi)似物)與ERT結(jié)合,可使Cre-ERT2進(jìn)核發(fā)揮Cre重組酶活性。
查看常見(jiàn)的基因工程小鼠可以分為兩種命名方式,包括基因定點(diǎn)修飾的小鼠命名,比如:敲除、敲入、點(diǎn)突變等等,和隨機(jī)轉(zhuǎn)基因的小鼠命名。
查看