Esr2-IRES-CreERT2
品系全名
C57BL/6Smoc-Esr2em1(IRES-CreERT2)Smoc
目錄號
NM-KI-234206
品系狀態(tài) 精子凍存
基因信息
基因名
Esr2
品系描述
驗證數(shù)據(jù)
Fig1. CreERT2 mediated recombination in ovary of Esr2CreERT2/+; Rosa26tdTomato/+ mouse.?
Fig2. Detection of tdTomato(red) in various tissues of female Esr2CreERT2/+; Rosa26tdTomato/+ mouse. TdTomato expression in tissues: eyeballs, heart, lungs, stomach, brown fat, pancreas, large intestine, ovaries, skin, muscles, thymus. Tissues with scattered expression: salivary glands, kidneys. Tissues with no expression: brain, spinal cord, liver, adrenal gland, small intestine, spleen, pituitary gland. Scattered expression missing in the control group: adrenal gland, ovaries.. (6-weeks old, female) (For more detailed information please contact our technical advisor.)?
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Cre-ERT2在無Tamoxifen誘導的情況下,在細胞質內處于無活性狀態(tài);當Tamoxifen誘導后,Tamoxifen的代謝產(chǎn)物4-OHT(雌激素類似物)與ERT結合,可使Cre-ERT2進核發(fā)揮Cre重組酶活性。
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