Syn1-IRES-CreERT2
品系全名
C57BL/6Smoc-Syn1em1(IRES-CreERT2)Smoc
目錄號
NM-KI-231789
品系狀態(tài)
活體
基因信息
基因名
Syn1
品系描述
驗證數(shù)據(jù)
Fig 1. Cre-mediated recombination in brain of Syn1CreERT2/+; Rosa26tdTomato/+ mice.
Fig 2. Cre-mediated recombination in brain of Syn1CreERT2/+; Rosa26tdTomato/+ mice.
Fig 3. Detection of tdTomato (red) in various tissues of Syn1CreERT2/+; Rosa26tdTomato/+ mice. Expression tissues include: brain, retina, islet, pituitary. A few cells expressed in spinal cord, heart, lung, liver, adrenal gland, kidney, small intestine, colon, muscle and thymus. Tissues that unexpressed include? stomach, salivary glands, brown fat, spleen, uterus, skin. Tamoxifen induction began at 35 days of age, with testing at 45 days. (45-day old, female) (For more detailed information please contact our technical advisor.)?
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Cre-ERT2在無Tamoxifen誘導(dǎo)的情況下,在細(xì)胞質(zhì)內(nèi)處于無活性狀態(tài);當(dāng)Tamoxifen誘導(dǎo)后,Tamoxifen的代謝產(chǎn)物4-OHT(雌激素類似物)與ERT結(jié)合,可使Cre-ERT2進(jìn)核發(fā)揮Cre重組酶活性。
查看常見的基因工程小鼠可以分為兩種命名方式,包括基因定點修飾的小鼠命名,比如:敲除、敲入、點突變等等,和隨機轉(zhuǎn)基因的小鼠命名。
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