Pdx1-2A-Cre

品系全名

C57BL/6Smoc-Pdx1em(2A-Cre)1Smoc

目錄號

NM-KI-225082

品系狀態(tài)

胚胎凍存

導(dǎo)出PDF

基因信息

基因名
pdx1

基因曾用名

Ipf1， IDX-1， IPF-1， Mody4， STF-1， pdx-1

NCBI ID

MGI ID

Ensembl ID

Pubmed

品系描述

將2A-Cre插入到小鼠Pdx1基因終止密碼子處。

驗證數(shù)據(jù)

image.png

Fig1. Cre mediated recombination in pancreasof Pdx1Cre/+;Rosa26tdTomato/+?mice.

The white dashed line indicates the islets of langerhans.

image.png

Fig2. Cre mediated recombination in brunner's glands? of Pdx1Cre/+;Rosa26tdTomato/+?mice.

image.png

Fig3. Detection of tdTomato(red) in various tissues of of Pdx1Cre/+;Rosa26tdTomato/+?mouse. Expression tissues include: pancreas, lung, small intestine, kidney, colon. A few cells expressing it were also identified in the liver, adrenal gland, muscle, thymus, subcutaneous tissue. Tissues that unexpressed include:brain, retina, heart, stomach, salivary glands, brown fat, spinal cord, spleen, testis, epidermis, pituitary gland.

你也可能感興趣

Tamoxifen誘導(dǎo)Cre-ERT2小鼠 使用指南

Cre-ERT2在無Tamoxifen誘導(dǎo)的情況下，在細(xì)胞質(zhì)內(nèi)處于無活性狀態(tài)；當(dāng)Tamoxifen誘導(dǎo)后，Tamoxifen的代謝產(chǎn)物4-OHT（雌激素類似物）與ERT結(jié)合，可使Cre-ERT2進核發(fā)揮Cre重組酶活性。

查看
【小鼠大學(xué)問】基因工程小鼠的命名規(guī)則

常見的基因工程小鼠可以分為兩種命名方式，包括基因定點修飾的小鼠命名，比如：敲除、敲入、點突變等等，和隨機轉(zhuǎn)基因的小鼠命名。

查看