Col1a1-IRES-CreERT2
品系全名
C57BL/6Smoc-Col1a1em(IRES-CreERT2)1Smoc
目錄號
NM-KI-225031
品系狀態(tài) 活體
基因信息
基因名
Col1a1
品系描述
驗證數(shù)據(jù)
Fig1. Cre mediated recombination in femur of Col1a1CreERT2/+;Rosa26tdTomato/+ mouse.?
Fig2. Detection of tdTomato(red) in various tissues of Col1a1CreERT2/+;Rosa26tdTomato/+ mouse. Expression tissues include: lung, stomach, teeth, pancreas, small intestine, colon, spleen, epididymis, skin, pituitary gland and skull. A few cells expressed in brain, eyeball, heart, liver, salivary gland, adrenal gland, kidney, muscle, thymus. Tissues that unexpressed include spinal cord, brown fat.The control group is expressed before induction. (39-days old, male) (For more detailed information please contact our technical advisor.)?
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Cre-ERT2在無Tamoxifen誘導的情況下,在細胞質(zhì)內(nèi)處于無活性狀態(tài);當Tamoxifen誘導后,Tamoxifen的代謝產(chǎn)物4-OHT(雌激素類似物)與ERT結(jié)合,可使Cre-ERT2進核發(fā)揮Cre重組酶活性。
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