Cldn18-IRES-CreERT2
品系全名
C57BL/6Smoc-Cldn18em(IRES-CreERT2)1Smoc
目錄號(hào)
NM-KI-225024
品系狀態(tài)
精子凍存
基因信息
基因名
Cldn18
品系描述
驗(yàn)證數(shù)據(jù)
Fig1. CreERT2 mediated recombination in stomach of Cldn18 CreERT2/+;Rosa26 tdTomato/+ mice
Fig2. Detection of tdTomato(red) in various tissues of Cldn18 CreERT2/+;Rosa26 tdTomato/+ mice. The organization of tdTomato expression: stomach, lung, brown fat. Tissues that do not express tdTomato: brain, spinal cord, eyeball, heart, liver, salivary glands, adrenal glands, kidneys, pancreas, large intestine, small intestine, spleen, reproductive system, muscles, skin, thymus, pituitary gland. (37-days old, male) (For more detailed information please contact our technical advisor.)?
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Cre-ERT2在無(wú)Tamoxifen誘導(dǎo)的情況下,在細(xì)胞質(zhì)內(nèi)處于無(wú)活性狀態(tài);當(dāng)Tamoxifen誘導(dǎo)后,Tamoxifen的代謝產(chǎn)物4-OHT(雌激素類似物)與ERT結(jié)合,可使Cre-ERT2進(jìn)核發(fā)揮Cre重組酶活性。
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