Trp63-CreERT2
品系全名
C57BL/6Smoc-Trp63em(CreERT2-WPRE-polyA)Smoc
目錄號
NM-KI-225021
品系狀態(tài) 精子凍存
基因信息
基因名
Trp63
品系描述
驗證數(shù)據(jù)
Fig1. Cre mediated recombination in bladder of Trp63CreERT2/+;Rosa26tdTomato/+ mouse.?
Fig2. Detection of tdTomato(red) in various tissues of Trp63CreERT2/+;Rosa26tdTomato/+ mouse. Expression tissues include: bladder, skin, cornea, stomach, salivary gland, thymus. A few cells expressed in kidney and spleen. Tissues that unexpressed include brain, spinal cord, heart, lung, liver, brown fat, pituitary, pancreas, small intestine, colon, ovary and uterus, skeletal muscle, adrenal gland. (53-day old, female) (For more detailed information please contact our technical advisor.)?
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Cre-ERT2在無Tamoxifen誘導的情況下,在細胞質(zhì)內(nèi)處于無活性狀態(tài);當Tamoxifen誘導后,Tamoxifen的代謝產(chǎn)物4-OHT(雌激素類似物)與ERT結(jié)合,可使Cre-ERT2進核發(fā)揮Cre重組酶活性。
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