Lum-2A-CreERT2
品系全名
C57BL/6Smoc-Lumem1(2A-CreERT2)Smoc
目錄號(hào)
NM-KI-210447
品系狀態(tài)
精子凍存
基因信息
基因名
Lum
品系描述
驗(yàn)證數(shù)據(jù)
Fig1. Cre mediated recombination in Cornea of LumCreERT2/+;Rosa26tdTomato/+ mouse. (ep, epithelium; st, stroma.)
Fig2. Cre mediated recombination in skin of LumCreERT2/+;Rosa26tdTomato/+ mouse.?
Fig3. Detection of tdTomato(red) in various tissues of LumCreERT2/+;Rosa26tdTomato/+ mouse. Expression tissues include: cornea, skin, stomach, small intestine, colon, spleen and adrenal gland. A few cells expressed in spinal cord, salivary gland, thymus. Tissues that unexpressed include brain, heart, lung, liver, brown fat, pituitary, kidney, pancreas and testis. (9-week old, male) (For more detailed information please contact our technical advisor.)?
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Cre-ERT2在無(wú)Tamoxifen誘導(dǎo)的情況下,在細(xì)胞質(zhì)內(nèi)處于無(wú)活性狀態(tài);當(dāng)Tamoxifen誘導(dǎo)后,Tamoxifen的代謝產(chǎn)物4-OHT(雌激素類似物)與ERT結(jié)合,可使Cre-ERT2進(jìn)核發(fā)揮Cre重組酶活性。
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