hIL2/hIL2RA/hIL2RB/hIL2RG

品系全名

C57BL/6Smoc-Il2tm3(hIL2)Il2ratm1(hIL2RA)Il2rgem1(IL2RG)Il2rbtm1(hIL2RB)Smoc

目錄號(hào)

NM-HU-210415

品系狀態(tài)

活體

導(dǎo)出PDF

基因信息

基因名

基因曾用名

Il-2;CD25，Il2r，Ly-43;gc，p64，[g]c，CD132，gamma?;p70，CD122，IL15Rbeta，Il-2Rbeta，IL-15Rbeta，Il-2/15Rbeta

NCBI ID

16183，16184，16186，16185

MGI ID

96548，96549，96551，96550

Pubmed

人類同源基因

IL2，IL2RA，IL2RG，IL2RB

品系描述

通過hIL2/hIL2RA(NM-HU-200275)和hIL2RA/hIL2RB/hIL2RG(NM-HU-210414)交配獲得。

驗(yàn)證數(shù)據(jù)

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Fig1. Detection of hIL-2 expression by ELISA in the hIL-2 knockin mice?(Wild type and heterozygous hIL-2 KI mice were administrated with concanavalin).

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Fig2. Intracellular staining of IL-2 by FACS post stimulation with anti-mCD3/anti-mCD28?(In collaboration with CrownBio).

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Fig3. IL-2RA humanized mouse expresses hlL-2RA (hCD25) on na?ve Treg in blood?(In collaboration with CrownBio).

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Fig4. hlL-2RA is highly expressed on activated Tregs in spleen in the IL-2RA huamnzied mouse?(In collaboration with CrownBio).

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Fig5. hlL-2RA is highly expressed on activated NK cells in spleen in the IL-2RA humanized mouse?(In collaboration with CrownBio).

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Fig6. Immunotype in hIL2/hIL2RA/hIL2RB/hIL2RG qKI mice.

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Fig7. Immunotype in hIL2/hIL2RA/hIL2RB/hIL2RG qKI mice in Blood.

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Fig8. Immunotype in hIL2/hIL2RA/hIL2RB/hIL2RG qKI mice in Spleen.

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Fig9. Detection of Signaling integrity in hIL2/hIL2RA/hIL2RB/hIL2RG qKI mice.

Note.?Splenocytes of C57BL/6 mice were treated with anti-mCD3 and mIL-2(10 ng/ml) for 72h. Splenocytes of hIL2/hIL2RA/hIL2RB/hIL2RG qKI mice were treated with anti-mCD3 and hIL-2(10 ng/ml) for 72h.

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