hIL11/hIL11RA

品系全名

C57BL/6Smoc-Il11em1(hIL11)Il11ra1tm1(hIL11RA)/Smoc

目錄號(hào)

NM-HU-210372

品系狀態(tài)

胚胎凍存

導(dǎo)出PDF

基因信息

基因名

基因曾用名

IL-11，NR1，GP130，Il11ra，Il-11ra，Il11ra2，AI314697

NCBI ID

MGI ID

Pubmed

人類同源基因

IL11;IL11RA

品系描述

通過hIL11(NM-HU-204981)和hIL11RA (NM-HU-204982)小鼠交配獲得。
應(yīng)用領(lǐng)域：藥物篩選；免疫治療

驗(yàn)證數(shù)據(jù)

image.png

Fig.1 Detection of IL11 expression in testis,stomach and lung by RT-PCR in hIL11/hIL11RA?dKI mice.?

Wild type: only one band at 171 bp with primers F1/R1(mIl11);

Homozygous: only one band at 162 bp with primers F2/R2(hIL11).?

Abbr. M, DNA marker; HO, homozygous; WT, wild type.

image.png

Fig.2 Detection of IL11RA expression in testis, stomach and lung by RT-PCR?in hIL11/hIL11RA dKI?mice.??

Wild type: only one band at 289 bp with primers F1/R1(mIl11ra);

Homozygous: only one band at 247 bp with primers F2/R2(hIL11RA).

Abbr. M, DNA marker; HO, homozygous; WT, wild type.

image.png

Fig.3 Detection of hIL11 expression in lung homogenate by ELISA in hIL11/hIL11RA?dKI mice.?

Abbr. HO, homozygous; WT, wild type.?

Note. hIL11/hIL11RA and C57BL/6 mice were injected with LPS.

image.png

Fig.4 Detection of human IL11RA expression in hIL11/hIL11RA dKI mice by WB.?

Abbr. HO, homozygous; WT, wild type.

Note. The IL11RA Antibody cross-reacted with mouse and humanized IL11RA.?

image.png

Fig.5 Detection of hIL11RA expression in Kidney in C57BL/6 and HO/HO hIL11/hIL11RA knockin mice by IHC.?

Abbr. HO/HO, homozygous; WT, wild type.?

Note. The IL11RA Antibody cross-reacted with mouse and humanized IL11RA.?

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