hCCR8(2)

品系全名

C57BL/6Smoc-Ccr8em3(hCCR8)/Smoc

目錄號

NM-HU-2000054

品系狀態(tài)

胚胎凍存

導(dǎo)出PDF

基因信息

基因名
CCR8

基因曾用名

Cmkbr8

NCBI ID

MGI ID

Ensembl ID

Pubmed

人類同源基因

CCR8

品系描述

通過同源重組，將小鼠基因Ccr8進行人源化修飾。與此相似的品系還有hCCR8(NM-HU-190053)，詳細信息請咨詢技術(shù)顧問。
應(yīng)用領(lǐng)域：免疫治療；藥物篩選

驗證數(shù)據(jù)

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Fig1. Expression characterization of CCR8 humanized mouse.?

(A) Human CCR8 expression on activated splenic CD4+, CD8+ and Treg cells upon anti-mCD3/mCD28 stimulation in hCCR8 mice; (B) Statistics of T cell populations in hCCR8 mice.

image.png

Fig2. The anti-hCCR8 therapeutic antibody shows potent antitumor efficacy in hCCR8 mice.?

(A) and (B) in vivo antitumor response of anti-hCCR8 in hCCR8 mice bearing MC38 tumor.

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Fig3. In vivo antitumor responses of anti-hCCR8 alone or in combination with anti-PD-1 in hCCR8 knockin mice engrafted with MC38 tumor.?

(A) Mean tumor growth curves upon treatment; (B) Individual tumor growth curves upon treatment.

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Fig4. In vivo efficacy study in CCR8 humanized mice grafted with MC38 tumor model. JTX-1811 can inhibit the growth of MC38 xenografts (A) without significant effect on the body weight of CCR8 humanized mice (B).(provided by partner)

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