hCSF1R(2)
品系全名
C57BL/6Smoc-Csf1rem3(hCSF1R)Smoc
目錄號
NM-HU-190074
品系狀態(tài)
胚胎凍存
基因信息
基因名
CSF1R
品系描述
驗(yàn)證數(shù)據(jù)
Fig1. Detection of CSF1R(2) expression in spleen? by RT-PCR.?Wild type: only one band at 233 bp with primers F1/R1(mCsf1r(2));Homozygous: only one band at 345 bp with primers F2/R2(hCSF1R(2)); Abbr.. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.
Fig2. Detection of hCSF1R expression in blood and bone marrow in hCSF1R(2) KI mice.
Fig3. FPA008 and human CSF-1R test Ab can effectively inhibit the growth of bone marrow cells in hCSF1R mice, confirming that this model is an appropriate platform for human anti-CSF-1R antibody evaluation.（FPA008，BMS，phase II）
Fig4. Dose-dependent effect of huCSF-1R inhibitors on block the proliferation of macrophages in hCSF1R mice.
你也可能感興趣
Cre-ERT2在無Tamoxifen誘導(dǎo)的情況下，在細(xì)胞質(zhì)內(nèi)處于無活性狀態(tài)；當(dāng)Tamoxifen誘導(dǎo)后，Tamoxifen的代謝產(chǎn)物4-OHT（雌激素類似物）與ERT結(jié)合，可使Cre-ERT2進(jìn)核發(fā)揮Cre重組酶活性。
查看常見的基因工程小鼠可以分為兩種命名方式，包括基因定點(diǎn)修飾的小鼠命名，比如：敲除、敲入、點(diǎn)突變等等，和隨機(jī)轉(zhuǎn)基因的小鼠命名。
查看
