hIGF1R(2)

品系全名

C57BL/6Smoc-Igf1rtm(hIGF1R)Smoc

目錄號

NM-HU-230053

品系狀態(tài)

活體

導(dǎo)出PDF

基因信息

基因名
Igf1r

基因曾用名

hyft; CD221; IGF-1R; D930020L01; A330103N21Rik

NCBI ID

MGI ID

Ensembl ID

Pubmed

人類同源基因

IGF1R

品系描述

利用同源重組，將小鼠Igf1r 基因進行人源化修飾。

驗證數(shù)據(jù)

image.png

Fig.1 Detection of human IGF1R expression in female homozygous hIGF1R(2) knockin mice.?(n=3 in both groups, 7-week-old WT mice and 6-week-old hIGF1R mice)

Abbr. M, marker; WT, wild type; HO, Homozygous.

image.png

Fig.2 Detection of hIGF1R expression in the lung of female homozygous hIGF1R(2) knockin mice. (n=3 in both groups, 7-week-old WT mice and 6-week-old hIGF1R mice)

Abbr.? WT, wild type; HO, homozygous.

image.png

Fig.3 Detection of hIGF1R expression in the brain of female homozygous hIGF1R(2) knockin mice. (n=3 in both groups, 7-week-old WT mice and 6-week-old hIGF1R mice)

Abbr.? WT, wild type; HO, homozygous.

image.png

Fig.4 Detection of hIGF1R expression in the kidney of female homozygous hIGF1R(2) knockin mice. (n=3 in both groups, 7-week-old WT mice and 6-week-old hIGF1R mice)

Abbr.? WT, wild type; HO, homozygous.

image.png

Fig.5 Detection of lymphcytes subsets in the spleen of female hIGF1R(2) knockin mice by FACS. (n=3 in both groups, 7-week-old WT mice and 6-week-old hIGF1R mice)

Abbr.? WT, wild type; HO, homozygous.

image.png

Fig.6 Detection of myeloid cells in the spleen of female hIGF1R(2) knockin mice by FACS. (n=3 in both groups, 7-week-old WT mice and 6-week-old hIGF1R mice)

Abbr.? WT, wild type; HO, homozygous.

你也可能感興趣

Tamoxifen誘導(dǎo)Cre-ERT2小鼠 使用指南

Cre-ERT2在無Tamoxifen誘導(dǎo)的情況下，在細(xì)胞質(zhì)內(nèi)處于無活性狀態(tài)；當(dāng)Tamoxifen誘導(dǎo)后，Tamoxifen的代謝產(chǎn)物4-OHT（雌激素類似物）與ERT結(jié)合，可使Cre-ERT2進核發(fā)揮Cre重組酶活性。

查看
【小鼠大學(xué)問】基因工程小鼠的命名規(guī)則

常見的基因工程小鼠可以分為兩種命名方式，包括基因定點修飾的小鼠命名，比如：敲除、敲入、點突變等等，和隨機轉(zhuǎn)基因的小鼠命名。

查看