Foxp3-IRES-DTR-2A-tdTomato(BALB/c)

品系全名

BALB/cAnSmoc-Foxp3em9(IRES-DTR-2A-tdTomato)Smoc

目錄號(hào)

NM-KI-200213

品系狀態(tài)

胚胎凍存

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基因信息

基因名
Foxp3

基因曾用名

sf; JM2; scurfin

NCBI ID

MGI ID

Ensembl ID

Pubmed

人類同源基因

FOXP3

品系描述

將IRES-DTR-2A-tdTomato共表達(dá)結(jié)構(gòu)插入到小鼠Foxp3基因終止密碼子處。
應(yīng)用領(lǐng)域：DTR工具鼠；調(diào)節(jié)性T細(xì)胞

驗(yàn)證數(shù)據(jù)

CT 26 tumor cells were injected into FOXP3-DTR mice administered with different treatment, and Balb/c mice, respectively. And tumor growth curves of each group were recorded.

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Fig 1.?The growth of CT26 tumors in Foxp3-IRES-DTR-2A-tdTomato mice administered with different treatment and Balb/c mice.?(In collaboration with CrownBio)


Proportion of different type-specific T cells and macrophages in peripheral blood?of each group analyzed using FACS

image.png

Fig 2.?The percentage?of different type-specific T cells and macrophages?in peripheral blood of CT26?tumor-bearing Foxp3-IRES-DTR-2A-tdTomato mice administered with different treatment and Balb/c mice is detected by FACS.?(In collaboration?with CrownBio)


Proportion of different type-specific T cells and macrophages?in spleen and tumor of each group analyzed using FACS

image.png

Fig 3.?The percentage?of different type-specific T cells and macrophages in spleen and tumor of of CT26?tumor-bearing Foxp3-IRES-DTR-2A-tdTomato mice administered with different treatment and Balb/c mice is detected by FACS.?(In collaboration?with CrownBio)

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Fig 4. DTR? mediated cell knockout? in spleen of Foxp3-DTR/tdTomato mice (BALB/c).

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Fig 5. DTR? mediated cell knockout? in mesenteric lymph nodes of Foxp3-DTR/tdTomato mice(BALB/c).?

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