Zap70-W163C(Balb/c)

品系全名

BALB/cAnSmoc-Zap70em(W163C)Smoc

目錄號(hào)

NM-KI-210366

品系狀態(tài)

活體

導(dǎo)出PDF

基因信息

基因名
Zap70

基因曾用名

Srk; mur; mrtle; ZAP-70

NCBI ID

MGI ID

Ensembl ID

Pubmed

人類同源基因

ZAP70

品系描述

將小鼠Zap70基因表達(dá)蛋白的163位氨基酸由W替換為C，建立該Zap70基因點(diǎn)突變小鼠模型。
應(yīng)用領(lǐng)域：類風(fēng)濕性關(guān)節(jié)炎模型，強(qiáng)直性脊柱炎模型，SKG模型

疾病預(yù)測(cè)

類風(fēng)濕關(guān)節(jié)炎
Rheumatoid Arthritis

近似模型的表型

參考文獻(xiàn)

Sakaguchi N, Takahashi T, Hata H, Nomura T, Tagami T, Yamazaki S, Sakihama T, Matsutani T, Negishi I, Nakatsuru S, Sakaguchi S, Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice. Nature. 2003 Nov 27;426(6965):454-60

驗(yàn)證數(shù)據(jù)


image.png

Fig.1 Clinical score of joint swelling in HO Zap70-W163C (Balb/C) mice(A) and representative diagram of hind limb joints of mice in each group on day 52(B) (female, 6-8wks). Compared with the control group, the mannan-induced mice gradually increased their joint swelling scores over time.

Signs of arthritis were assessed by a visual score where 0= Normal paw, 1 = one toe inflamed or swollen, 2 = more than one toe, but not entire paw, or mild swelling of the entire paw, 3 = entire paw inflamed and swollen, and 4 = very inflamed and swollen paw or ankylosed paw.

image.png

Fig.2 Hindlimb micro-CT image of HO Zap70-W163C(Balb/C) mice in? the control (G1) and model groups (G2) (female, 6-8wks). The orange arrows point to osteophytes.

image.png

Fig.3 Score of HO Zap70-W163C(Balb/C) mice (A) and H&E pathology(B). (female, 6-8wks, n=3)

Compared with G1, the infiltration of mixed inflammatory cells in the induced group was significantly increased, and the synovial membrane of the joints showed obvious hyperplasia, pannu formation, fibrous tissue formation, and cartilage erosion.

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