hCCR8(BALB/c)(2)

品系全名

BALB/cAnSmoc-Ccr8em(hCCR8)Smoc

目錄號

NM-HU-220501

品系狀態(tài)

胚胎凍存

導(dǎo)出PDF

基因信息

基因名
CCR8

基因曾用名

Cmkbr8

NCBI ID

MGI ID

Ensembl ID

Pubmed

人類同源基因

CCR8

品系描述

利用同源重組，將小鼠Ccr8 基因進(jìn)行人源化修飾。

驗(yàn)證數(shù)據(jù)

image.png

Fig1. Detection of hCCR8 expression on spleen-derived activated T cells and Tregs in hCCR8 KI mice.

*Splenocytes were activated by anti-mCD3/CD28 antibody in vivo.image.png

Fig2. In vivo antitumor responses of anti-hCCR8 alone in BALB/c hCCR8(v2) knockin mice engrafted with CT26 tumor.?

(A) Mean tumor growth curves upon treatment; (B) In vivo antitumor response of anti-hCCR8 in hCCR8 (v2) mice bearing CT26 tumor; (C) Expression of hCCR8 in spleen in hCCR8 (v2) mice bearing CT26 tumor.image.png

Fig3. In vivo antitumor responses of anti-hCCR8 alone or in combination with anti-CTLA-4 in BALB/c hCCR8(v2) knockin mice engrafted with CT26 tumor.?

(A) Mean tumor growth curves upon treatment; (B) Individual tumor growth curves upon treatment; (C) In vivo antitumor response of anti-hCCR8 in hCCR8 (v2) mice bearing CT26 tumor.

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